GENEX®

Discover a precisely balanced β-tricalcium phosphate/calcium sulfate hemihydrate compound that is the perfect partner for your trauma and non-unions – complementing the body’s natural healing processes, then vanishing without a trace.

Perfect partner for your trauma and non-unions

genex is a catalyst for bone healing. It complements the body’s natural healing processes and encourages normal bone structure to be restored at a steady rate. Over 12 months, the graft matrix is completely absorbed and replaced by bone 1,2. No foreign artifacts are left behind to impair structural integrity.

  • Approved for bony voids and defects that are not intrinsic to structural stability.
  • An innovative, versatile choice that supports natural healing, then vanishes without a trace.

References: 1. Yang, H.L., et al., Bone healing response to a synthetic calcium sulfate/beta-tricalcium phosphate graft material in a sheep vertebral body defect model. J Biomed Mater Res B Appl Biomater, 2012. 100B(7): p. 1911-21. 2. Data on file, Mr Nissar & Mr Gopal. Patents granted EP 1390086 B1, US 8632796, CN1265846C US 8496955.

Designed to be completely absorbed and leave no trace1,2

genex is a precisely balanced β-tricalcium phosphate/calcium sulfate hemihydrate compound with distinct design properties:

  • Contains no hydroxyapatite (HA)
  • Negatively charged surface chemistry

genex provides a powerful scaffold for accelerated bone restoration and helps to hinder soft tissue ingrowth:

  • Fully absorbed within 12 months
  • Enhances osteogenic response
  • Restores strong healthy bone

Completely absorbed within 12 months1,2

genex Implantation

 6 Weeks

8 Weeks

 36 Weeks

genex contains no hydroxyapatite. HA can only be absorbed  at 1–2% per year5

(Large animal model. Decalcified histology H&E stain)

Enhances the osteogenic response to accererate bone growth – 5x normal levels6

Restores strong healthy bone within a clinically relevant timeframe,2,3

Tibial plataeu fracture

Post operative

15 months

genex restores bone to normal trabecular structure in 36 weeks1

References:1.Yang, H.L., et al., Bone healing response to a synthetic calcium sulfate/beta-tricalcium phosphate graft material in a sheep vertebral body defect model. J Biomed Mater Res B Appl Biomater, 2012. 100B(7): p. 1911-21.2.Data on file, Mr A Nissar and Mr S Gopal.3.Data on file, Mr HK Sharma.4.Pina, S. and J.M.F. Ferreira, Bioresorbable Plates and Screws for Clinical Applications: A Review. Journal of Healthcare Engineering, 2012. 3(2).5.Cooper, J.J., J.A. Hunt, and F. Pu, Enhancing the Osteogenic Potential of Bioabsorbable Implants through Control of Surface Charge., in Society for Biomaterials 2007 Annual Meeting. 2007: Chicago, Illinois, USA.

Versatility at your fingertips

genex is versatile and easy to prepare. It comes as a paste or putty in a range of volumes. The paste sets within 15 minutes, at body temperature, and can be digitally implanted or injected in difficult-to-reach sites, or minimally invasive procedures.

Transform outcomes

genex offers successful long-term outcomes across a range of surgical applications, including tibial plateau fractures and long-bone non-unions.

Use of genex in tibial plateau fracture

Patient presented with: Comminuted Schatzker type II fracture of right leg. X-ray examination revealed 2 large fragments and several small fragments.

Outcome: At 15 months’ follow-up the fracture had healed and knee was stable, with a range of motion of 0–130°. genex had completely absorbed.

Use of genex in proximal femur fracture

Patient presented with: Failed intramedullary nailing of an extracapsular neck of femur fracture. Patient complained of prominent metalwork and pain.

Outcome: At 12 months’ follow-up the fracture had healed with complete absorption of genex. Patient had a good range of hip motion and was able to walk and manage stairs.

Use of genex in distal tibia non-union

Patient presented with: Healed fibula with a non-union of the distal tibia and a fracture through the nail, 19 months after the initial operation.

Outcome: At 10 months’ follow-up the non-union had healed completely, patient had fully recovered and was scheduled to have the intramedullary nail removed.

The science of genex

Engineered for bone healing

How to prepare

genex

How to prepare

genex ds