STIMULAN is a pharmaceutical-grade calcium sulfate that is the perfect partner for your infection management strategy – helping you to improve surgical outcomes and lower overall costs of care.

Perfect partner for your infection management strategy

STIMULAN is a truly absorbable calcium sulfate, specifically designed to complement your dead space and infection management strategies.1

  • Approved for placement directly at the site of infection in bone and soft tissue
  • May be mixed with antibiotics to protect the device from colonisation by bacteria*

*The treating physician is responsible for deciding the type and quantity of antibiotic used.  For indications, contraindications, warnings and precautions see Instructions for Use.

The mixing of antibiotics with the STIMULAN Kit / STIMULAN Rapid Cure device has not been assessed by a European medicines Competent Authority and is considered off-label usage of the medicinal product.  To do so is at the professional risk of the surgeon / healthcare professional.


Patents granted: GB2367552, EP 1204599 B1, US 6780391, EP 2594231 B1, US 8883063, ZL 201210466117.X, GB2496710/Patents pending: GB 1502655.2, EP 16154210.5, US 15/040075, CH 201610089710.5

Recrystallised for improved clinical performance

STIMULAN has a unique crystal structure and properties.1,2

  • Controlled purity
  • May be mixed with liquid, powder and heat-sensitive antibiotics*

Only STIMULAN undergoes a patented recrystallization process that starts with pharmaceutical-grade reagents and results in its consistent and reliable performance.1–8

  • Predictable elution profile
  • Truly absorbable at an optimal rate
  • Low levels of drainage

Antibiotic elution from STIMULAN Rapid Cure™9

Truly absorbable and totally synthetic calcium sulfate – absorbs at an optimal rate1–5,8
Leaves no nidus for infection.


1 month

11 weeks

6 months

Low levels of drainage2–3, 6–7, 10–12

No third body damage13
Less scratching than competitor calcium sulfate and PMMA.

*The treating physician is responsible for deciding the type and quantity of antibiotic used. For indications, contraindications, warnings and precautions see Instructions for Use.

References: 1. Cooper JJ. Method of producing surgical grade calcium sulphate. 1999, Patent GB 2367552; EP 1204599; 6780391.  2. McPherson EJ. Dissolvable antibiotic beads in treatment of periprosthetic joint infection – the use of synthetic pure calcium sulfate (STIMULAN®) impregnated with vancomycin and tobramycin. Presented at: Oxford Bone Infection Conference (OBIC) 2012.  3. McPherson EJ et al. Reconstructive Review 2013;3:32–43.  4. Cierny G et al. Comparing OsteoSet and Stimulan as antibiotic-loaded, calcium sulfate beads in the management of musculoskeletal infection. Presented at: Musculoskeletal Infection Society of North America 2009. 5. Kallala R et al. Outcomes following use of antibiotic-eluting, absorbable, calcium sulfate beads in revision hip and knee surgery for periprosthetic infection. Presented at: International Society for Technology in Arthroplasty 2013. 6. Gauland C. The use of antibiotic impregnated, implanted synthetic calcium sulfate tablets in the treatment of soft tissue, vancomycin resistant enterococcus infections. Presented at: Wound Healing Society 2011.  7. Borrelli J, Jr et al. Clin Orthop Relat Res 2003;411:245–254. 8. Biocomposites Ltd, STIMULAN Instructions for use. 9. Cooper et al. Antibiotic stability in a synthetic calcium sulphate carrier for local delivery. Poster presented at European Bone and Joint infection Society Annual Meeting, Prague, Czech Republic, 2013. 10. Helgeson MD et al. Orthopedics 2009;32:323. 11. McKee MD et al. J Orthop Trauma 2002;16:622–627. 12. Noor S et al. Bone Joint J 2013;95-B:4.13.Data on file.

Case-by-case flexibility

STIMULAN can be used in three sizes of bead, as a paste or for injection, to optimise packing in bone and soft tissue. Its hydrophilic properties and options of rapid or standard setting times make it quick and easy if mixed with one or more antibiotics – helping you to adapt to each case as is merited.*

Flexible formats to optimise dead space management

Transform outcomes

STIMULAN can transform outcomes in infected non-unions, osteomyelitis and periprosthetic joint infection.

Transform osteomyelitis in diabetic foot

Patient presented with: persistent osteomyelitis and interphalangeal joint destruction of left hallux. He was already receiving treatment for Charcot arthropathy to his right foot.

Outcome: 2 weeks post-operatively, the toe reduced in size. At the 16-month x-ray the patient was infection-free and amputation had been avoided. STIMULAN was seen to have completely absorbed at 4 months.

Transform infected trauma

Patient presented with: infected femoral nail and non-union of left femur with persistent discharging wounds proximally and distally.

Outcome: At 7 months follow-up there was a complete healing of the non-union and at 1 year patient remains infection free, walking with no pain.

Transform infected revision arthroplasty

Patient presented with: infected total knee replacement 2 years after primary procedure.

Outcome: At 1 year follow-up the patient remains infection free and is under regular follow-up.


Hear what surgeons have to say about STIMULAN


Hear what surgeons have to say about STIMULAN

How to prepare

Hear what surgeons have to say about STIMULAN